A REVIEW ON VARIOUS APPROACHES OF PRODRUGS IN DRUG DEVELOPMENT
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati – 517561, Andhra Pradesh, India
Subhashis Debnath
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati – 517561, Andhra Pradesh, India
K. Vamsi
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati – 517561, Andhra Pradesh, India
L. Kranthi
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati – 517561, Andhra Pradesh, India
M. Niranjan Babu
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati – 517561, Andhra Pradesh, India
Prodrug refers to a pharmacological inactive compound that is converted to an active drug by a metabolic biotransformation. It is observed that about 10% of the drugs approved worldwide is classified as prodrugs. They are designed in order to improve the physicochemical, biopharmaceutical and/or pharmacokinetic properties of pharmacologically potent compounds. This article describes the basic functional groups that are required to prodrug design, and highlights the major applications of the prodrug strategy, including the ability to improve oral absorption and aqueous solubility, increase lipophilicity, enhance active transport, as well as achieve site-selective delivery
7 , 1 , 2017
1 - 9
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