LIPID BASED DRUG DELIVERY SYSTEM: CLASSIFICATION, DRUG TRANSPORT ACROSS ENTEROCYTE, ROLE OF LIPID CHAIN LENGTH IN SUPPRESSION OF BODY FAT ACCUMULATION
NIMS Institute of Pharmacy, NIMS University P.O. Box 303121, Jaipur, India.
Govind Mohan
NIMS Institute of Pharmacy, NIMS University P.O. Box 303121, Jaipur, India.
Md. Hedaitullah
HIMT College of Pharmacy, Greater Noida (U.P), India.
Md. Khalid Iqbal
HIMT College of Pharmacy, Greater Noida (U.P), India.
The major challenge in the oral delivery of dosage form is poor absorption mainly due to the deficit aqueous solubility of drug that may lead to erratic bioavailability and hence therapeutic failure. It has been reported that about 40% of new chemical entities (NCEs) being short of aqueous solubility cannot be formulated conventionally. Every efforts made by the formulators to step-up the solubility and bioavailability of these entities. For this oral lipid based drug delivery system are attracting considerable attention due to their capacity to step-up the solubility, dissolution, facilitating gastrointestinal absorption and eliminate the effect of food on the absorption of poorly aqueous soluble or lipophilic drug and thereby increasing the bioavailability. Over the decades several strategies are being designed in lipid based drug delivery system had justified the remarkable improvement in bioavailability. This review highlighted the brief description of lipid absorption and transport across the enterocytes, drug candidate selection, potential screening of excipient intended for lipid based drug delivery, role of long, short and medium chain triglycerides in suppression of body fat accumulation, and Pouton’s classification for lipid based drug delivery system.
4 , 2 , 2014
98 - 108
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