RECENT TECHNOLOGIES IN PULSATILE DRUG DELIVERY SYSTEM
Department of Pharmaceutics, SND College of Pharmacy, Yeola (Nashik), India.
Mansuk Avinash
Department of Pharmaceutics, SND College of Pharmacy, Yeola (Nashik), India.
Lukkad Harish
Department of Pharmaceutics, SND College of Pharmacy, Yeola (Nashik), India.
ACT Sustained and controlled drug delivery system release the drug at a substantially steady rate of release per unit of time. However, there are instances where maintaining a constant blood level of a drug is not desirable. In such cases a pulsatile drug delivery may be more advantageous. Pulsatile drug delivery systems (PDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of thedisease resulting in improved patient therapeutic efficacy and compliance. Diseases wherein PDDS are promising include asthma, peptic ulcer cardiovascular diseases, arthritis attention deficit syndrome in children, and hypercholesterolemia. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system; stimuli induced PDDS in which release is controlled by the stimuli, like the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. The aim of this review is to introduce the concept of chronopharmaceutics, to cover the technologies that have been developed to achieve pulsatile delivery such as Pulsincap®, Diffucaps®, CODAS®, and PULSYSTM; which follow the above mechanism to render a sigmoidal drug release profile. Diseases wherein PDDS are promising include asthma, peptic ulcers, cardiovascular ailments, arthritis and attention deficit syndrome in children and hypercholesterolemia. Therefore, pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases.
4 , 2 , 2014
76 - 84
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