PREPARATION AND EVALUATION OF ORNIDAZOLE IN SITU GELLING SYSTEM FOR GASTRORETENTIVE DRUG DELIVERY
Department of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya, Karnataka-571422, India
S Parthiban
Department of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya, Karnataka-571422, India
S K Senthilkumar
Department of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya, Karnataka-571422, India
The main objective of this study was to develop floating in situ gelling system of ornidazole using sodium alginate gelling polymer and calcium chloride as cross-linking agent for potentially treating gastric ulcer, associated with helicobacter pylori. Alginate based ornidazole floating in situ gelling system were prepared by dissolving varying concentration of sodium alginate in deionized water containing calcium carbonate, to which drug was added and dissolved by stirring. The formulation variable like concentration of sodium alginate significantly affected the invitro drug release from the prepared formulations. It was concluded that prolonged gastrointestinal residence time and enhanced ornidazole stability resulting from the floating in situ gel of ornidazole might contribute better for complete eradification of H. pylori
3 , 2 , 2013
62 - 69
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