EXTRUSION-SPHERONISATION TECHNIQUE - A REVIEW
Department of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya, Karnataka - 571 422, India
Senthilkumar SK
Department of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya, Karnataka - 571 422, India
Extrusion-Spheronisation process is the most employed technique, it offers the advantage to incorporate high amounts of active pharmaceutical ingredient, without producing an excessively large particle of drug-loaded pellets apart from being more efficient than the other techniques for producing pellets. Today this technology has gained attention because of its simple and fast processing. Extrusion spheronization is widely utilized in formulation of sustained release, controlled release delivery system. This article discusses about the extrusion spheronization process and its application in pharmaceutical industry as well as focuses on modified process called as melt extrusion process utilized for formulation of sustained release tablets, transdermal delivery system and transmucosal delivery system in pharmaceutical industry
3 , 1 , 2013
20 - 25
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