FORMULATION AND EVALUATION OF BIFONAZOLE ORGANOGEL AS A NOVEL TOPICAL DRUG DELIVERY SYSTEM
Kottam Institute of Pharmacy, Mahabub nagar, Andhrapradesh, India- 509125
Arabinda Patnaik
Sanskrit College of pharmacy, Rangareddy, Andhrapradesh, India.-500084
N.Sriram
Smt.Sarojini Ramulamma College of Pharmacy, Mahabub nagar, Andhrapradesh, India-509001
V.Bharath Raju
Kottam Institute of Pharmacy, Mahabub nagar, Andhrapradesh, India- 509125
Bifonazole is a novel imidazole antifungal drug which has been used in many skin and nail infections caused by fungi. The aim of the present study is to improve availability of drug at the desired site by use of organogels such as pluronic lecithin and to check the suitability of pluronic lecithin organogels containing Bifonazole for topical application. Eight formulations were developed using Bifonazole, lecithin, Pluronic F127, isopropyl myristate, water, sorbic acid and potassium sorbate were coded as FL1 to FL8. For the preparation of FL1, FL2, FL3 and FL4, 20 % oil phase and 80 % aqueous phase were used while for FL5, FL6, FL7 and FL8, 30 % oil phase and 70 % aqueous phase were used. The formulated organogels were evaluated for appearance by psychorheologically, in vitro diffusion study, drug content, viscosity and pH. It was found that the pH of all the formulations is in the range of to 5.29 -6.58 that suits the skin pH, indicating skin compatability. This is the primary requirement for a good topical formulation. This fact reflects higher spreadability of pluronic organogels as compared to sorbitan Monostearate organogels. All formulation showed spreadability in the range of 12.79- 52.15 g.cm/sec
3 , 1 , 2013
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