A REVIEW ON CHROMATOGRAPHIC STRATEGIES FOR ANTIBIOTIC ANALYSIS IN PHARMACEUTICAL FORMULATIONS
Recent lookup have most reliable the contrast and optimization of ?-lactam antibiotics through innovative chromatographic, spectrometric, and pharmacokinetic approaches. Techniques such as HPLC, LC–MS/MS, and HPTLC have been developed and validated for unique quantification of antibiotics like ampicillin, sulbactam, ceftazidime, and polymyxin B in organic and pharmaceutical samples. These techniques have prolonged therapeutic drug monitoring, enabling individualized dosing in extensively sick victims and improving cure outcomes. Eco-friendly analytical strategies and biotechnological tools, which consists of genetically engineered microorganisms and CRISPR-based sensors, have in a similar way contributed to sustainable detection and degradation of antibiotic residues. Several research moreover explored the antimicrobial and antiinflammatory residences of natural merchandise such as Dinizia excelsa and Teucrium polium L., highlighting workable choices in opposition to resistant pathogens. Collectively, these findings emphasize the integration of analytical chemistry, pharmacokinetics, and environmental security to beautify antibiotic efficacy, minimize toxicity, and combat antimicrobial resistance. The multidisciplinary strategies added throughout these lookup form a sturdy groundwork for future tendencies in antibiotic lookup and sustainable pharmaceutical practices
15 , 2 , 2025
28 - 31
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