HOSPITALIZED PATIENT RISK MANAGEMENT INDICATOR: NARROW THERAPEUTICS INDEX
KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India
Nunavath Mounika
KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India
Mohammad Neha Afreen
KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India
Nishitha J
KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India
Maneesha
KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India
A narrow therapeutic index drug (NTI drug) differs little between its therapeutic and toxic dose; it is a drug with a small therapeutic and toxic pharmacokinetic range. These drugs do not have a known pattern of drug-related problem (DRP). In hospitalized patient, we investigated how drugs with a narrow therapeutic index (NTI-drugs), in comparison with various drugs, might be related to various types of drug-related problem. The study in 2022 enrolled patients from five internal medicine departments and rheumatology. In addition to demographics and drugs used, pharmacy technicians also recorded medical history and laboratory results. A comparison was made between patients taking NTI-drug (ciclosporin, digoxin, aminoglycosides, digoxin, flecainide, digitoxin, carbamazepine, phenytoin, lithium, warfarin, phenobarbital, theophylline, rifampicin) and those not taking NTI-drugs. Based on medical record reviews and assessments by hospital team, 8 varieties of DRPs were detected. Various drugs were divided by the number of DRPs based on the number of times they were used to calculate their drug risk ratio. 146 patients using NTI-drugs out of 415 took part in the study. There was a difference between non- NTI and NTI drugs in terms of how often they were associated with DRPs, 42% versus 17%, respectively. Drug risk ratios for non-NTI-drugs and NTI-drugs were 0.25 and 0.10, respectively. Non-optimal dosage, drug interactions, and monitoring requirements were significantly more frequent among NTI-drugs. Three of the eight DRP categories were associated with a higher occurrence of DRPs than those associated with non-NTIs
13 , 1 , 2023
5 - 9
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