EVALUATION OF ANTINOCICEPTIVE EFFECTS OF MELIA AZEDARACH LEAVES
* Independent Researcher, Shri Balaji Drugs INC, 8808 Camp Bowie West Blvd, Fort Worth, TX-76116, USA. 1 Sri Venkateswara College of Pharmacy, R.V.S Nagar, Chittoor Dist - 517127, Andhra Pradesh, INDIA
The growing interest in natural products for pain management, due to their potential for fewer side effects, has led to an exploration of Melia azedarach (Chinaberry tree), a plant with a rich history of medicinal use. This study investigates the antinociceptive effects of the methanolic extract of Melia azedarach leaves in murine models, using acetic acid-induced writhing and formalin-induced paw licking tests. The results indicate a dose-dependent reduction in nociceptive responses, with high doses (750 mg/kg) achieving inhibition rates comparable to the standard analgesic diclofenac sodium. In the formalin test, the extract demonstrated significant efficacy in both the neurogenic and inflammatory phases, suggesting action on both peripheral and central pain pathways. These findings support the potential of Melia azedarach as a natural analgesic, offering a promising alternative for pain relief with potentially reduced adverse effects. Further studies are recommended to isolate active compounds and clarify specific mechanisms of action.
5 , 2 , 2015
104 - 108
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