A CASE REPORT ON DRAVETS SYNROME IN A 4½YEAR OLD CHILD TREATED WITH ANTIEPILEPTIC DRUGS
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India
Merrin Joseph
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India
Lini Varghese
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India
Dravets syndrome is rare drug resistant epilepsy that often begins before the first year of life as febrile seizures. Most cases are due to SCN1A gene mutation. Intellectual development begins to deteriorate around the age of 2 years. A 4½year old child was admitted to pediatric ward at Nirmala Medical centre with complaints of convulsions and fever. According to the signs and symptoms child was diagnosed with seizure disorder associated with Dravets syndrome. The pharmacological management options for dravets syndrome include first line therapies ( valproate and clobazam),second line therapies(stiripentol,topiramate) and later options(leviteracetam).Clobazam can be used to reduce the severity of seizures in children with dravets syndrome usually in combination with other anticonvulsant such as sodium valproate. Sodium channel blockers are not used as they exacerbate seizures. This case report focuses on the use of antiepileptic drugs for the management of Dravet syndrome induced seizure disorder.
10 , 2 , 2020
8 - 10
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