PROSPECTIVE STUDY ON POTENTIAL DRUG – DRUG INTERACTIONS IN A SECONDARY CARE HOSPITAL
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India.
Alphine Roy
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India.
An Maria Jose
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India.
Harsha Rajesh
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India.
Johns Zacharia
Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, 686661 Kerala, India.
An interaction is said to occur when the effects of one drug are altered by the co-administration of another drug, herbal, medicine, food, drink or other environmental chemical agents. The net effect of combination may manifest as an additive or enhanced effect of one or more drugs, antagonism of the effect of one or more drugs or any alteration in effect. Drug – drug interactions are a particularly important type of adverse drug event because they are often predictable based on previous reports, clinical studies and an understanding of pharmacologic principles. Some adverse drug events have life threatening consequences and may prompt the removal of popular medications from the market place. The study was a prospective observational study, conducted in secondary healthcare center in Muvattupuzha. In this case study, a total of 150 cases were included and the study population consisted of the patients admitted to the general medicine department of Nirmala Medical Centre, Muvattupuzha during a period of 4 months. General medicine department of Nirmala Medical Centre, a private cooperate hospital in Muvattupuzha. Out of the analysed cases, 108 cases were found to have PDDIs with Major (30.601%), Moderate (31.694%) and Minor (37.705%) interactions. In our study, more number of drug interactions were identified in elderly patients of age group >60 years (53.703%). Of the total 108 patients, 43.518% of the study subjects were males and 56.482% were females. A total of 57 patients had one or more comorbidities. The most common comorbid conditions observed in our study patients include Hypertension (21.29%), Diabetes mellitus (18.51%), Migraine (3.70%),Hyperlipidemia (5.55%) and Coronary artery disease (3.70%). Majority of PDDIs were seen in patients receiving 4-5 drugs (32.407%).The lack of awareness regarding the management of PDDIs have affected the quality of life of the patients. DDIs, being an avoidable adverse event, prescriptions adhering to treatment guidelines and proper monitoring by health care professionals can decrease the rate of PDDIs to a great extent.
10 , 1 , 2020
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