FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF METHADONE ORO DISPERSIBLE TABLETS
Gollapudi Rajesh
Ajmera Ramarao
Ajmera Ramarao
Paladugu Sujitha
Paladugu Sujitha
Md Parveen
Md Parveen
In the present work, an attempt has been made to develop fast disintegrating tablets of methadone. In the present work Sodium starch glycollate, Cross povidoneand Crosscarmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. Camphor was employed as sublimating agent, due to presence of camphor maximum pores will be formed. As the number of pores were more the body fluid will penetrates more easily. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 98.78 % in 8 min hence it is considered as optimized formulation. The F4 formulation contains Cross Povidone as super disintegrate in the concentration of 12 mg.
7 , 2 , 2017
59 - 66
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