ELECTROCHEMICAL BEHAVIOUR AND VOLTAMMETRIC DETERMINATION OF BENTAZEPAM AT CARBON PASTE ELECTRODE
Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
D. Sri Vidya
Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
P.Aruna
Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
N.Y.Sreedhar
Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
The electrochemical behavior of bentazepam (BTZP) was investigated in pharmaceutical and human serum samples at carbon paste electrode (CPE) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The drug BTZP exhibits a well defined reduction peak over the potential range 0.30 V to -0.90 V in phosphate buffer solution (PB) of pH 2.0 to 8.0. An irreversible and diffusion controlled sharp reduction peak was observed at 4.0. The lower detection limit (LOD) and the lower limit (LOD) were found to be 4.23x10-9 molL-1 and 2.85x10-7 molL-1 respectively. The proposed method was successfully applied for the determination of BTZP in pharmaceutical and human urine samples
5 , 2 , 2015
72 - 76
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