RMULATION AND EVALUATION OF STAVUDINE MICROSPHERES USING EUDRAGIT RS100 AND ETHYLCELLULOSE
Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India
Baishakhi Dey
School of Medical Science & Technology, IIT Kharaghpur-721302, West Bengal, India
Koushik Bhandari
School of Medical Science & Technology, IIT Kharaghpur-721302, West Bengal, India
Prakash Katakam
Department of Pharmaceutics, Faculty of Pharmacy, University of Zawia, AzZawiyah, Libya
The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water-soluble drug, stavudine, using Eudragit RS100 and ethylcellulose as the retardant materials. Microspheres were prepared by solvent evaporation method using an acetone/liquid paraffin system. Magnesium stearate was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their micromeritic properties and drug loading, as well by Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The in vitro release studies were performed in pH 6.8 phosphate buffer. The prepared microspheres were white, free flowing and spherical in shape. The infrared spectra showed stable character of stavudine in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The drug-loaded microspheres showed 67-93% of entrapment and release was extended up to 11 to 12 h. The best-fit release kinetics was achieved with Higuchi plot followed by zero order and First order. The release of stavudine was influenced by the drug to polymer ratio and particle size and was found to be diffusion controlled. Formulation SF1 could be used as the most drug retarding microspheres using combination polymers of Eudragit RS100 and ethylcellulose
4 , 4 , 2014
219 - 225
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