DESIGN, DEVELOPMENT AND EVALUATION OF SOLIFENACIN SUCCINATE MODIFIED RELEASE MATRIX TABLETS USING NATURAL POLYMER
Vignan Colllege of pharmacy, Vadlamudi, Guntur, Andhra Pradesh, 522 213, India
Srinivasa Babu P
Vignan Colllege of pharmacy, Vadlamudi, Guntur, Andhra Pradesh, 522 213, India
Chandrasekar K.B
Jawaharlal Nehru Technological University Anantapur, Andhra Pradesh, 515 002, India
To design, develop and evaluate the modified release matrix tablets by controlled drug delivery system for antimuscarinic class drugs such as Solifenacin succinate with the objective overcome the existing problems using Hydroxypropyl methyl cellulose (HPMC K4M), Sodium carboxy methyl cellulose (NaCMC), Guar Gum and Xanthan Gum as rate controlling polymer for the treatment of overactive bladder. The tablets were prepared by wet granulation method and studied the effect of the matrix former such as Guar Gum and Xanthan Gum separately. Tablets were evaluated for uniformity of weight, drug content, friability, hardness, thickness, swelling study, in vitro drug release, kinetic studies and stability studies. All the formulation had shown compliance with pharmacopoeial standard. The drug release study shows that an increase amount of polymer resulted in retarded drug release. The maximum drug release was found to be 96% over a period of 24 hours in guar gum based formulations (SF 9-SF 12) at a concentration ranging from 15 to 60mg per tablet. Similarly maximum drug release was found to be 95% over a period of 24 hours in Xanthan gum based formulations (SF13-SF16) at a concentration ranging from 15 to 60mg per tablet. The drug release from optimized formulation (SF14) fitted to various kinetic models and the drug release was found to follow zero-order kinetics and diffusion release mechanism. The optimized formulation were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern. Results of the present study indicate the suitability of the above mentioned polymers in the preparation of controlled release formulation of Solifenacin
4 , 4 , 2014
207 - 214
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