EFFECT OF EUODIA HORTENSIS FORSTER EXTRACTS ON BRAIN BIOGENIC AMINES IN RATS
Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, Tirupati-517102, Andhra Pradesh, India
K.R. Vandana
Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, Tirupati-517102, Andhra Pradesh, India
A. Saravana Kumar
Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, Tirupati-517102, Andhra Pradesh, India
The stems of Euodia hortensis Forster is used traditional Indian medicine to treat epilepsy. Previous studies have demonstrated that extracts of these plants was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. The purpose of the present study is to investigate the effect of ethanolic (95%) extract of Euodia hortensis Forster (EEEH) on biogenic amines concentrations in rat brain after induction of seizures by MES and PTZ. Our aim of study was relationship between seizure activities and altered the monoamines such as noradrenaline (NA), dopamine (DA), serotonin (5-HT) and Gamma amino butyric acid (GABA) in forebrain of rats in MES and PTZ seizure models. In MES model, EEEH (250 & 500 mg/kg) showed significantly restored the decreased levels of brain monoamines such as NA, DA, 5-HT and GABA. Similarly in PTZ model, EEEH showed significantly increased the monoamines in forebrain of rats. Thus, this study suggests that ethanol extract of Euodia hortensis Forster increased the monoamines on rat brain, which may be decreased the susceptibility to MES and PTZ induced seizure in rats
1 , 1 , 2011
37 - 42
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