A SIMPLE VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF DULOXETINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
Department of Chemistry, Krishna Murthy institute of Technology and Engineering, College, Ranga Reddy (Dt), Andhra Pradesh, India
G Ramachandra Reddy
Department of Humanities, Ravindra College of Engineering, Kurnool, Andhra Pradesh, India
Shaik Obedulla Shariff
Department of Physics, Osmania College, Kurnool, Andhra Pradesh, India
N Rami Reddy
Department of Chemistry, S.B.S.Y.M. Degree College, Kurnool, Andhra Pradesh, India
A simple, sensitive, precise and economical visible spectrophotometric method has been developed for the determination of duloxetine hydrochloride in pharmaceutical formulations. The method is based on the charge transfer complexation reaction of duloxetine hydrochloride with 2, 3-Dichloro-5, 6-Dicyanobenzoquinone. Under the optimized experimental conditions Beer's law is obeyed in the concentration range of 20-100 μg/mL for the proposed method. The proposed method was found to be simple, sensitive, accurate, precise, rapid and economical for the routine quality control application of duloxetine hydrochloride in pharmaceutical formulations
4 , 1 , 2014
52 - 54
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