FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLETS OF PREDNISOLONE
Department of Pharmaceutics, Bharathi college of Pharmacy, Bharathinagara, Mandya, Karnataka – 571422, India
S K Senthilkumar
Department of Pharmaceutics, Bharathi college of Pharmacy, Bharathinagara, Mandya, Karnataka – 571422, India
S Parthiban
Department of Pharmaceutics, Bharathi college of Pharmacy, Bharathinagara, Mandya, Karnataka – 571422, India
The aim of the present work is to formulate and evaluate controlled porosity osmotic pump tablet of prednisolone to improve the bioavailability and target the drug to colon, this will also increase patient compliance. Osmotic pump tablets of prednisolone were prepared by making molecular inclusion with beta cyclodextrin. These inclusion complexes were used in the formulation of controlled porosity osmotic pump with different concentrations of osmogens. Wet granulation technique was employed in making the granules. Formulated tablet were characterized by pre-compression and post compression parameters. The in-vitro drug release studies were performed in phosphate buffer pH 6.8. All the results were in the standard limits of I.P. Formulated dosage form can be effective alternative to conventional dosage form, which can be effectively used in the treatment of several, Bowel disease, Ulcerative colitis, Crohn’s disease, Rheumatoid Arthritis, and Cancer, etc
3 , 2 , 2013
70 - 78
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