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Issn 2249-7579

e Issn 2249-7579

Publisher JOURNAL OF PHARMACEUTICAL BIOLOGY

Title

ISOLATION OF EUMELANIN FROM SEPIA OFFICINALIS AND INVESTIGATION OF ITS ANTIMICROBIAL ACTIVITY BY OINTMENT FORMULATION

Authors

Keywords

Cephalopod ,Sepia officinalis ,Cuttlefish ,Eumelanin ,Antimicrobial activity ,Ointment ,Framycetin ,

Abstract

Marine environment comprises of many organisms which are known to possess bioactive components as a common means of self-defense or for the protection of eggs and embryos. Cephalopods are famous for their defenses, from their fast jetting escape movements to changes in coloration that can be puzzling or mysterious, startling to release of toxic venom and to inking. The cephalopod fish we have selected is Sepia officinalis, a common cuttle fish or European common cuttle fish, one of the largest and best known cuttlefish species. It has an ink gland to protect itself as a defense. The ink has main constituent, eumelanin. An ointment of eumelanin was prepared with various concentrations of eumelanin and is evaluated for various parameters like appearance, pH, loss of drying, viscosity, spreadability, drug content, drug permeation studies etc. The presence of antimicrobial activity in sepia ink has been evaluated by measuring zone of inhibition of the formulated ointment in nutrient agar. Antimicrobial activity of the ointment was tested by comparison with the standard marketed formulation of Framycetin. Thus we conclude that the sepia ink possesses antimicrobial activity due to the presence of the eumelanin polymer

Volume / Issue / Year

2 , 2 , 2012

Starting Page No / Endling Page No

67 - 72

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