EFFECT OF MALACHRA CAPITATA (L.) EXTRACTS ON BIOGENIC AMINES CONCENTRATIONS IN RAT BRAIN AFTER INDUCTION OF SEIZURE
Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andhra Pradesh, India
A. Saravana Kumar
Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andhra Pradesh, India
The roots of Malachra capitata (L.) are used traditional Indian medicine to treat epilepsy. Previous studies have demonstrated that extracts of these plants was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. The purpose of the present study is to investigate the effect of aqueous (95%) extract of Malachra capitata (L.) (AMC) on biogenic amines concentrations in rat brain after induction of seizures by MES and PTZ. Our aim of study was relationship between seizure activities and altered the monoamines such as noradrenaline (NA), dopamine (DA), serotonin (5-HT) and Gamma amino butyric acid (GABA) in forebrain of rats in MES and PTZ seizure models. In MES model, AMC (200 & 400 mg/kg) showed significantly restored the decreased levels of brain monoamines such as NA, DA, 5-HT and GABA. Similarly in PTZ model, AMC showed significantly increased the monoamines in forebrain of rats. Thus, this study suggests that aqueous extract of Malachra capitata (L.) increased the monoamines on rat brain, which may be decreased the susceptibility to MES and PTZ induced seizure in rats
2 , 2 , 2012
54 - 58
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