FORMULATION & DEVELOPMENT OF GLIPIZIDE FAST DISSOLVING TABLETS USING A NATURAL GUM AS SUPER DISINTEGRANT
M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.
B. Venkateswarlu naik
M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.
G.Prasanthi
M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.
G. Jhansi rani
M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.
K. Vijaya kumari
M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.
V. Srinivasa rao
M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.
The objective of the present research work is to develop a fast dissolving tablet of Glipizide with a view to provide rapid control over high blood sugar levels and also to increase the bioavailability. For this purpose natural fenugreek gum was selected as a super disintegrating agent which also possess antidiabetic activity. Owing to its antidiabetic property the fenugreek gum not only acts as super disintegrant but also provides better control over blood sugar levels in combination with glipizide. The method used was UV Spectrophotometric method was used for estimation of glipizide. The Rheological studies indicated that the 1% w/v gum dispersions of Fenugreek gum in water had a gel like consistency. Direct compression technique was employed for the formulation because it was easy to fabricate & all the excipients complied with this technique. In vitro dissolution study results revealed that there was a significant rise in the release rate with the increment in the concentration of the disintegrating agents. The drug release from all the formulations ascertained first order kinetics.
7 , 1 , 2017
23 - 28
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